Drs. Victoria Bae-Jump (associate Professor OB/GYN) and Liza Makowski (assistant professor, Nutrition) have just published a manuscript entitled “Obesity increases tumor aggressiveness in a genetically engineered mouse model of serous ovarian cancer” in a special issue of Gynecologic Oncology entitled, “The Obesity Crisis: Impact of Gynecologic Cancer.” The project was funded by UNC funds (UCRF, NORC and NCTracs), as well as DOD, and NIH, among others.

Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L. Metabolic reprogramming of macrophages: Glucose Transporter (GLUT1)-mediated glucose metabolism drives a pro- inflammatory phenotype. J Biol Chem. 2014 Feb 3. [Epub ahead of print] PMID 24492615 2014

Sundaram S, Freemerman AJ, Johnson AR, Milner JJ, McNaughton KK, Galanko JA, Bendt KM, Darr DB, Perou CM, Troester MA, Makowski L. Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat. 2013 Nov 12. Link:

Sundaram S, Johnson AJ, Makowski L Obesity, metabolism and the microenvironment: Links to cancer;year=2013;volume=12;issue=1;spage=19;epage=19;aulast=Sundaram 

Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, and Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci USA. Jul 17;109(29):11818-23. Epub 2012 Jun 29. PMID: 22752304

Sampey BP, Freemerman AJ, Zhang J, Kuan PF, Galanko JA, O’Connell TM, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Newgard CB, Brauer HA, Troester MA, Makowski L. Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers that Drive Obesity-Associated Inflammation. PLoS One. 2012;7(6):e38812. Epub 2012 Jun 12. PMID: 22701716

Stewart DA, Yang Y, Makowski L, Troester MA. Basal-like breast cancer cells induce phenotypic and genomic changes in macrophages in vitro. Molecular Cancer Research. 2012 Jun;10(6):727-738. Epub 2012 Apr 24. PMID: 22532586 2012.

Sun X, Casbas-Hernandez P, Bigelow C, Makowski L, Jerry DJ, Schneider SS, Troester MA. Normal Breast Tissue of Obese Women is Enriched For Macrophage Markers And Macrophage-Associated Gene Expression. Breast Cancer Res Treat. 2011 Oct 15. [Epub ahead of print] PMID:22002519

Ang MK, Patel MR, Yin X, Sundaram S, Fritchie K, Zhao N, Liu Y, Freemerman AJ, Wilkerson MD, Walter V, Weissler MC, Shockley WW, Couch ME, Zanation AM, Hackman TG, Chera BS, Harris SL, Miller CR, Thorne L, Hayward MC, Funkhouser W, Olshan AF, Shores CG, Makowski L, Hayes DN. High XRCC1-protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2011 Oct 15;17(20):6542-6552. Epub 2011 Sep 9.PMID:21908577

Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L. Obesity (Silver Spring). 2011 Jun;19(6):1109-17. Epub 2011 Feb 17.  PMID:21331068

Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures. Sampey BP, Lewis TD, Barbier CS, Makowski L, Kaufman DG. Exp Mol Pathol. 2011 Jun;90(3):257-63. Epub 2011 Jan 31. PMID:21281625

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Nat Med. 2009 Dec;15(12):1383-91. Epub 2009 Nov 29. Erratum in: Nat Med. 2010 Feb;16(2):237.  PMID:19966778

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.  Makowski L, Noland RC, Koves TR, Xing W, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Muoio DM. FASEB J. 2009 Feb;23(2):586-604. Epub 2008 Oct 22. PMID:18945875

Role of LKB1 in lung cancer development. Makowski L, Hayes DN.  Br J Cancer. 2008 Sep 2;99(5):683-8. Epub 2008 Aug 19. Review. PMID:18728656

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Nature. 2007 Jun 21;447(7147):959-65. Epub 2007 Jun 6. PMID:17554340

Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Brüning JC. Cell Metab. 2006 Apr;3(4):247-56. Erratum in: Cell Metab. 2006 Jun;3(6):469. Tobe, Kazuyuki [added]; Kadowaki, Takashi [added].  PMID:16581002,_Issue_4,_Pages_231-300_(April_2006)%23tagged%23Volume%23first%3D3%23Issue%23first%3D4%23date%23(April_2006)%23&view=c&_gw=y&wchp=dGLbVzz-zSkWA&md5=bfe8aeb2300ea28ec2bfc6a158a788e9&ie=/sdarticle.pdf

The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis. Makowski L, Hotamisligil GS. Curr Opin Lipidol. 2005 Oct;16(5):543-8. Review. PMID:16148539

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. J Biol Chem. 2005 Apr 1;280(13):12888-95. Epub 2005 Jan 31. PMID:15684432

Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Circulation. 2004 Sep 14;110(11):1492-8. Epub 2004 Sep 7. PMID:15353487

Fatty acid binding proteins–the evolutionary crossroads of inflammatory and metabolic responses. Makowski L, Hotamisligil GS. J Nutr. 2004 Sep;134(9):2464S-2468S. Review. PMID:15333743

Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Maeda K, Uysal KT, Makowski L, Görgün CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Diabetes. 2003 Feb;52(2):300-7. PMID:12540600

Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1686-91. PMID:12377750

Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF.Nat Med. 2001 Jun;7(6):699-705. PMID:11385507

Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS. Diabetes. 1999 Oct;48(10):1987-94. PMID:10512363

Stability of human plasma leptin concentrations within 36 hours following specimen collection. Chu NF, Makowski L, Hotamisligil GS, Rimm EB. Clin Biochem. 1999 Feb;32(1):87-9. No abstract available.  PMID:10074899



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